Pseudomyxoma peritonei

Ruptured mucocele with foreign body peritonitis
Male: cystadenocarcinoma of appendix
Female: cystadenocarcinoma of ovary

*Thickening of peritoneal + omental sufaces
*Omental cake
*Posterior fixation of bowel loops and mesentery
*Voluminous septated/loculated pseudoascites
*Several thin-walled cystic masses of different size throughout abdominal cavity
*Scalloped contour of liver and splenic margins
Annular / semicircular calcifications

GIST

Esophageal GIST

Gastric GIST

Staging of colon cancer

Modified Duke Staging System
Modified Duke A
The tumor penetrates into the mucosa of the bowel wall but no further.
Modified Duke B
B1: tumor penetrates into, but not through the muscularis propria (the muscular layer) of the bowel wall.
B2: tumor penetrates into and through the muscularis propria of the bowel wall.
Modified Duke C
C1: tumor penetrates into, but not through the muscularis propria of the bowel wall; there is pathologic evidence of colon cancer in the lymph nodes.
C2: tumor penetrates into and through the muscularis propria of the bowel wall; there is pathologic evidence of colon cancer in the lymph nodes.
Modified Duke D
The tumor, which has spread beyond the confines of the lymph nodes (to organs such as the liver, lung or bone).
TNM Staging System (Tumor, Node, Metastisis)
Tumor
T1: Tumor invades submucosa.
T2: Tumor invades muscularis propria.
T3: Tumor invades through the muscularis propria into the subserosa, or into the pericolic or perirectal tissues.
T4: Tumor directly invades other organs or structures, and/or perforates.
Node
N0: No regional lymph node metastasis.
N1: Metastasis in 1 to 3 regional lymph nodes.
N2: Metastasis in 4 or more regional lymph nodes.
Metastasis
M0: No distant metastasis.
M1: Distant metastasis present.

Von Hippel-Lindau Disorder

•Autosomal dominant disorder (Chroosome 3) with 1/35000-1/40000 incidence in America
•Most attacked in 2nd to 3rd decades
•M:F is about 1:1
Diagnostic Criteria
•> 1 hemangioblastoma of CNS
•1 hemangioblastoma + visceral manifestation
•1 manifestation + family history

Subclassification by NIH

•Type I: Renal + pancreatic cysts, high risk for RCC, no pheochromocytoma
•Type IIA: Pheochromocytoma, pancreatic islet cell tumor
•Type IIB: Pheochromocytoma + renal + pancreatic disease

Angiomatous lesions

- Retinal hemangioblastomas -> Von Hippel tumor
- CNS hemangioblastomas -> Lindau tumor
- Endolymphatic sac tumors
- Renal cell carcinoma - Pancreatic cysts and tumors
- Pheochromocytomas
- Epididymal cystadenomas

Squamous cell carcinoma

30% of lung cancer
Related to smoking
65% found in main, lobar, or segmental bronchi
Endobronchial mass
Bronchial obstruction
Infiltration of bronchial wall
Local invasion
Hilar mass
Atelectasis and consolidation common
30% solitary nodule or mass
Central necrosis and cavitation relatively common
Metastasis late
Relatively good prognosis